Why statins cause myopathy

Proper assessment of patients will assist in the recognition of patients at risk. Knowledge of the currently available statins and their properties will enable pharmacists to provide appropriate recommendations for individualized treatment regimens. Once patients are initiated on statin therapy, pharmacists have the opportunity to monitor patient adherence, treatment response, and medication safety, in addition to providing ongoing patient education on statin therapy and its adverse effects.

Pharmacists should continue to counsel patients on the risk and warning signs of statin-associated myopathy, as the incidence underscores the need for pharmacists to play a direct role in the monitoring of statin therapy in the inpatient and outpatient setting. Updated April Accessed September 21, Narrative review: statin-related myopathy. Ann Intern Med.

Evidence-based management of statin myopathy. Curr Atheroscler Rep. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients—the PRIMO study. Cardiovasc Drugs Ther. For consumers. FDA: Limit use of 80 mg simvastatin. Updated June Accessed January 10, The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr Opin Lipidol. Risk factors and drug interactions predisposing to statin-induced myopathy.

Drug Saf. Hodel C. Myopathy and rhabdomyolysis with lipid-lowering drugs. Toxicol Lett. Statin-induced myopathy: a review and update. Expert Opin Drug Saf. Circ Res. Decreases in serum ubiquinone do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.

Clin Pharmacol Ther. Marcoff L, Thompson PD. The role of CoQ10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol. Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia. Am J Cardiol. Sathasivam S, Lecky B. Statin-induced myopathy. Ann Pharmacother. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.

Rosenson R. I looked at her and said how can I pass if I didnt feel anything If she could have she would have picked me up and thrown me out the door. Hello Pat.

I am so sorry you are having so much trouble with this. People there are very responsive and helpful. My 47 yr. He was hit with a very rare disease called Antisynthetase, look it up. His enzyme levels were up to 17,, should be under Has had to take high doses daily of steroids to reduce those levels, and this caused him terrible sleep deprivation which is torture. He has had 2 infusions of rutuxin and hopefully, his body will begin to respond and go into remission.

Imagine feeling pain every minute in so many areas of your body, and not sleeping properly. He goes to rehab for muscle 2xweek. He uses a cane and walker now. This is a mean and unforgiving disease.

My husband is 68 and has been on Lipitor for 4 or 5 years. Gradually there were red flags that we look back on.

The middle of July because ha said he was so tired his PCP and his cardiologist both told him to stop the Lipitor. Then he got so weak his doctor sent him to the ER on August 12th and was in the hospital for three days then went to a rehab facility. On Sept 16th he was moved to another facility. He has almost zero mobility. Can only move his arms up a little. Most often, this is the solution. The authors declare that there are no conflicts of interest regarding the publication of this paper.

This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article of the Year Award: Outstanding research contributions of , as selected by our Chief Editors. Read the winning articles. Journal overview. Academic Editor: Mario Salazar-Paramo. Received 01 Jul Accepted 01 Sep Published 01 Oct Abstract Statins are notorious for causing myalgia and sometimes mild elevation of CPK creatine phosphokinase.

Introduction Statin-associated myopathy or myalgia is a well-known side effect of lipid-lowering agents. Case Presentation A year-old African American female with a past medical history significant for type 2 insulin-dependent diabetes mellitus, hypertension, hypercholesterolemia, severe osteoarthritis of the left shoulder, moderate degenerative disc disease of lumbar spine, gout, chronic kidney disease stage III, and chronic pancreatitis was referred to rheumatology with complains of weakness in her upper extremities proximal muscles for about one month.

Figure 1. CPK levels during statin therapy, before presenting to Rheumatology Clinic. Figure 2. CPK levels after statin re-challenge and initiation of immunosuppressive therapy. Table 1. Figure 3. Figure 4. References M. George, N. McGill, and J. Bitzur, H. Cohen, Y. Kamari, and D. S—S, Albayda and L. Allenbach, J. Keraen, A. Bouvier et al. Allenbach, L. Arouche-Delaperche, C. Preusse et al. Grable-Esposito, H. Katzberg, S. Greenberg, J.

Srinivasan, J. Katz, and A.